Digitalize complex in vivo and in vitro workflows to boost accuracy and traceability from start to finish
At IDBS, we understand the critical role that drug metabolism and pharmacokinetics (DMPK) studies play in drug development. IDBS Polar simplifies complex in vivo and in vitro DMPK workflows by automating study setup, execution and analysis. This boosts data integrity and study reproducibility with unified traceability that accelerates decision making and strengthens regulatory readiness.
DMPK workflow and insight accelerators are also available to get labs up and running faster with pre-configured workflows, analytics and reporting.
Built-in flexibility in treatment groups & time points
Built-in randomization tool
Plate layout definition
Worklist generation
Buffers, reagents and test samples prepared
Experiment and assay execution
Integration with Sciex, Analyst and other instruments
Link study data to associated work, materials and equipment and capture change history, provenance and chain-of-custody
Bring together data and results from all in vivo and in vitro DMPK workflows
Reduce transcription errors from paper/Excel workflows
Full traceability from study design to results; capture linkage of PK parameters with raw data
Access data for cross-study comparisons
Curve fitting with outlier exclusion
Calculated concentration for unknown samples
Non-compartmental analysis (NCA) by subject and treatment group
Collaborate & share data between sponsors, CxOs and multi-sites
Use cross-study comparisons to learn and improve study design and parameters
Built-in ALCOA+, GxP standards for audit trails and traceability across reintegration or re-runs
Complete data set for bioanalytical method validation
Our DMPK workflow and insight accelerators are designed to standardize and streamline both in vivo and in vitro workflows, empowering scientists to generate high-quality, reproducible data faster and with greater confidence.
The DMPK workflow accelerators support key in vivo and in vitro activities from study sample creation to analytical testing and computational analysis of results. The associated insight dashboard enables comparison of results across multiple studies, focusing on both standard stability and study outcomes.
The in vivo workflow accelerator
Simplify the complexity of animal-based studies with a structured, intuitive workflow. The in vivo accelerator supports:
This workflow ensures consistency across studies, reduces manual errors and accelerates time to insight.
The in vitro workflow accelerator
Optimize your in vitro studies with a flexible, scalable workflow that supports:
Whether you’re working with liver microsomes, hepatocytes or plasma, our in vitro accelerator helps you generate reliable data to predict drug behavior early in development.
Transform raw pharmacokinetics data into actionable insights with the DMPK insight app – a powerful tool purpose-built for non-compartmental analysis (NCA). Designed for pharmacokineticists and bioanalysts, the insight accelerator enabled:
With the DMPK insight app, you can reduce analysis time, eliminate manual processing errors, and gain a clearer understanding of your compound’s pharmacokinetic profile.
Learn the importance of data integration and management in biopharmaceutical development, and how IDBS’ solutions can improve decision-making.
Talk on “Streamlining upstream development: an integrated digital backbone to combine product and process insight for a more efficient path to success.”
IDBS cut cell line development reporting timelines by 50%. It supports hundreds of users globally at a biotechnology company focusing on biologic therapeutics.
*Customer data on file at IDBS. This result was originally obtained using IDBS E-WorkBook; IDBS Polar delivers the same or higher gains as IDBS E-WorkBook in a like-for-like implementation, with added value from advanced analytics, AI/ML and reporting.
