Preclinical data represents a different data management challenge. In common with HCS, preclinical scientists collect a variety of different data types (including textual, image and instrument output data) from a relatively few number of subjects. E-WorkBook for biology (BioBook) represents a unique way to capture these disparate data types, within a CFR 21 part 11-ready environment. Novel multi-dimensional spreadsheet technology and direct import of data from external sources makes BioBook, E-WorkBook's biology component, a powerful and flexible solution for late stage discovery/preclinical complete electronic study management.